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Merck
모든 사진(1)

주요 문서

SML3254

Sigma-Aldrich

Aloperine

≥98% (HPLC)

동의어(들):

Alop1 compound,(7-alpha,9-alpha)-9-De-2-piperidinyl-16,17-didehydro-ormosanine, ALO, (6R,6aR,13R,13aS)-1,3,4,6,6a,7,8,9,10,12,13,13a-Dodecahydro-6,13-methano-2H-dipyrido[1,2-a:3′,2′-e]azocine, Ormosanine

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About This Item

실험식(Hill 표기법):
C15H24N2
CAS Number:
Molecular Weight:
232.36
MDL number:
UNSPSC 코드:
12352107
NACRES:
NA.77

Quality Level

분석

≥98% (HPLC)

양식

powder

광학 활성

[α]/D 73 to 89°, c = 0.5 g/mL in ethanol

색상

white to beige

mp

67-72 °C

solubility

DMSO: 2 mg/mL, clear

저장 온도

−20°C

SMILES string

[H][C@]12CN3CCCC[C@]3([H])[C@]([H])(C1)C=C4CCCN[C@@]24[H]

InChI

1S/C15H24N2/c1-2-7-17-10-13-9-12(14(17)5-1)8-11-4-3-6-16-15(11)13/h8,12-16H,1-7,9-10H2/t12-,13+,14+,15+/m0/s1

InChI key

SKOLRLSBMUGVOY-GBJTYRQASA-N

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일반 설명

Aloperine is a quinolizidine-type alkaloid found in the seeds and leaves of the herbal plant, Sophora alopecuroides L. It possesses antiviral, anticancer, antioxidant, and anti-inflammatory activity. Aloperine exhibits antifibrotic activity in mouse models of pulmonary fibrosis, and anticancer activity in human osteosarcoma and thyroid cancer cells. It also exhibits neuroprotective effects against oxidative stress in early brain injury, and antiviral activity as a human immunodeficiency virus-1 (HIV-1) entry inhibitor. Aloperine also has the ability to inhibit migration and invasion of liver cancer cells, as well as disrupt the cell cycle, and mitigate cell growth at various phases. It can hinder the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway.

애플리케이션

Aloperine may be used to study its effects on allergic airway inflammation in the murine asthma model and to compare its anti-asthmatic activity.

생화학적/생리학적 작용

Alkaloid with antiviral, anticancer, antioxidant, and anti-inflammatory activity

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

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