SML3123

NButGT

≥98% (HPLC)

• 동의어(들): (3aR,5R,6S,7R,7aR)-3a,6,7,7a-Tetrahydro-5-(hydroxymethyl)-2-propyl-5H-pyrano[3,2-d]thiazole-6,7-diol
• 실험식(Hill 표기법): C₁₀H₁₇NO₄S
• CAS Number: 863918-55-2
• Molecular Weight: 247.31
• UNSPSC 코드: 41106609
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: -10 to -25°C
• SMILES string: CCCC1=N[C@@H]2[C@H]([C@@H]([C@H](O[C@@H]2S1)CO)O)O

설명

생화학적/생리학적 작용

NButGT is a potent and selective inhibitor of O-GlcNAcase (OGA), which elevates O-GlcNAc levels but does not cause insulin resistance in 3T3-L1 adipocytes, and in rats and mice. NButGT does not perturbed glucohomeostasis when used for extended time in rats and mice. NButGT attenuates the accumulation of Aβ, neuroinflammation, and memory in in a mouse model of Alzheimer’s disease. NButGT efficiently increased total O-GlcNAc, improves cardiovascular function and reduced animal mortality in rat model of sepsis.

Specific and potent inhibitor of O-GlcNAcase (OGA)

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable