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Merck
모든 사진(1)

주요 문서

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SML3070

Sigma-Aldrich

PSEM89S Hydrochloride salt

≥98% (HPLC)

동의어(들):

(S)-2,5-Dimethoxy-N-(quinuclidin-3-yl)benzamide, Hydrochloride salt, N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide Hydrochloride salt, PSEM 89S Hydrochloride salt, PSEM-89S Hydrochloride salt

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C16H22N2O3 · HCl
CAS Number:
1221570-55-3
Molecular Weight:
326.82
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

저장 조건

desiccated

색상

white to beige

solubility

DMSO: 2 mg/mL, clear

저장 온도

2-8°C

SMILES string

O=C(N[C@@H]1CN2CCC1CC2)C3=C(C=CC(OC)=C3)OC.Cl

InChI

1S/C16H22N2O3.ClH/c1-20-12-3-4-15(21-2)13(9-12)16(19)17-14-10-18-7-5-11(14)6-8-18;/h3-4,9,11,14H,5-8,10H2,1-2H3,(H,17,19);1H/t14-;/m1./s1

InChI key

OHMFVSNTNXNVRE-PFEQFJNWSA-N

생화학적/생리학적 작용

PSEM agonist for chimeric ligand-gated ion channel pores with nAChR α7 LBD L141F or L141F/Y115F mutant (PSAM) in vitro and in vivo.
PSEM89S is a pharmacologically selective effector molecule (PSEM) that acts as a selective agonist in vitro and in vivo for chimeric pharmacologically selective actuator modules (PSAMs) composed of nAChR α7 ligand-binding domain (LBD) with L141F mutation fused to the ion pore domain (IPD) of a ligand-gated ion channel (LGIC), including glycine receptor (PSAML141F-GlyR & PSAML141F/Y115F-GlyR). 5-HT3 (PSAML141F-5-HT3 & PSAML141F/Y115F-5-HT3) and high-conductance 5-HT3 (PSAML141F-5-HT3 HC & PSAML141F/Y115F-5-HT3 HC).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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