SML2981

EN219

≥98% (HPLC)

• 동의어(들): 1-(3,5-bis(4-Bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-chloroethanone, 3,5-bis(4-Bromophenyl)-1-(chloroacetyl)-4,5-dihydro-1H-pyrazole
• 실험식(Hill 표기법): C₁₇H₁₃Br₂ClN₂O
• CAS Number: 380351-29-1
• Molecular Weight: 456.56
• MDL number: MFCD02989881
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: Brc1ccc(cc1)C2N(NC(=C2)c3ccc(cc3)Br)C(=O)CCl
• InChI key: PREWPJFURADJST-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

EN219 is a cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination. EN219 is shown to covalently interact with RNF114-C8 (IC50 = 470 nM), TUBB1-C201, HSPD1-C442, and HIST1H3A-C97. EN219 is a recruiter of the E3 ubiquitin ligase RNF114 that can be utilized for PROTAC applications.

cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable