SML2812

AN1

≥98% (HPLC)

• 동의어(들): 5-Bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one, mHTT-LC3 linker AN1
• 실험식(Hill 표기법): C₁₅H₉Br₂NO₃
• CAS Number: 486443-73-6
• Molecular Weight: 411.04
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: Brc1c(c(cc(c1)C=C2c3c(ccc(c3)Br)NC2=O)O)O
• InChI: 1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)
• InChI key: GPKLWRHHVIBYEO-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

AN1 is a brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation. AN1 significantly lower mHTT in cortices of HD mice, in cells from patients with Huntington′s disease, and neurons derived from induced pluripotent stem cells. AN1 does not lower wtHTT in fibroblasts from healthy human donors. It appears that AN1 interact with the polyQ stretch.

brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable