SML2782

Br-PBTC

≥98% (HPLC)

• 동의어(들): (R)-7-Bromo-N-(piperidin-3-yl)benzo[b]thiophene-2-carboxamide, 7-Bromo-N-(3R)-3-piperidinylbenzo[b]thiophene-2-carboxamide
• 실험식(Hill 표기법): C₁₄H₁₅BrN₂OS
• CAS Number: 1839519-57-1
• Molecular Weight: 339.25
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C(C1=CC(C=CC=C2Br)=C2S1)N[C@@H]3CCCNC3
• InChI: 1S/C14H15BrN2OS/c15-11-5-1-3-9-7-12(19-13(9)11)14(18)17-10-4-2-6-16-8-10/h1,3,5,7,10,16H,2,4,6,8H2,(H,17,18)/t10-/m1/s1
• InChI key: LRYYPTVUWGMZQB-SNVBAGLBSA-N

설명

생화학적/생리학적 작용

Br-PBTC is a selective and potent type II positive allosteric modulator (PAM) that potentiates the opening of the nicotinic acetylcholine receptors (nAChR) subtypes containing α4β2, α2β2 and α2β4 subunits. Br-PBTC potentiates opening and reactivates desensitized (α4β2)2α4 nAChRs. It appears that Br-PBTC interacts with extracellular C-terminus of α2 or α4 in association with nearby parts of the α subunit.

selective and potent type II PAM that potentiates the opening of the nAChR subtypes containing α4β2, α2β2 and α2β4 subunits.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3