SML2675
CuET
≥97% (HPLC)
동의어(들):
Copper bis(N,N-diethyldithiocarbamate), Cupric diethyldithiocarbamate, Merkupral, NSC 177697, bis(N,N-Diethyldithiocarbamato)copper(II)
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C10H20CuN2S4
CAS Number:
Molecular Weight:
360.09
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
분석
≥97% (HPLC)
양식
powder
저장 조건
desiccated
색상
dark green to black
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
CCN(CC)C(S[Cu]SC(N(CC)CC)=S)=S
InChI
1S/2C5H11NS2.Cu/c2*1-3-6(4-2)5(7)8;/h2*3-4H2,1-2H3,(H,7,8);/q;;+2/p-2
InChI key
OBBCYCYCTJQCCK-UHFFFAOYSA-L
생화학적/생리학적 작용
CuET, a metabolite of disulfiram, is an inhibitor of p97 segregase adaptor NPL4 that exhibits potent anti-cancer effects. Apparently CuET binds NPL4 and induces its aggregation, which disables the vital p97–NPL4–UFD1 pathway and induces to cell death.
Inhibitor of NPL4
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Tomoya Fujie et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 21(2), 263-273 (2016-01-31)
The interest in organic-inorganic hybrid molecules as molecular probes for biological systems has been growing rapidly. Such hybrid molecules exhibit unique biological activities. Herein, copper(II) bis(diethyldithiocarbamate) (Cu10) was found to activate the transcription factor NF-E2-related factor 2 (Nrf2), which is
Zdenek Skrott et al.
Nature, 552(7684), 194-199 (2017-12-07)
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing. Here we highlight the potential for repurposing disulfiram (also
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