SML2642
S29434
≥98% (HPLC)
동의어(들):
N-[2-(2-Methoxy-6H-dipyrido[2,3-a:3′,2′-e]pyrrolizin-11-yl)ethyl]-2-furancarboxamide, S 29434, [2-(2-methoxy-5H-1,4b,9-triaza(indeno[2,1-a]inden-10-yl)ethyl]-2-furamide
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C21H18N4O3
CAS Number:
Molecular Weight:
374.39
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
[n]21c3c(nc(cc3)OC)c(c2c5ncccc5C1)CCNC(=O)c4[o]ccc4
InChI
1S/C21H18N4O3/c1-27-17-7-6-15-19(24-17)14(8-10-23-21(26)16-5-3-11-28-16)20-18-13(12-25(15)20)4-2-9-22-18/h2-7,9,11H,8,10,12H2,1H3,(H,23,26)
InChI key
XJIUMLVQBQKCJA-UHFFFAOYSA-N
생화학적/생리학적 작용
S29434 is a cell and blood-rain barrier penetrant, potent and selective inhibitor of quinone reductase 2 (QR2, NQO2) that inhibits production of ROS by QR2 in cells. S29434 triggers autophagy in human HepG2 cells. S29434 enhances exploring time of the unfamiliar object in mice memory test.
blood-brain barrier penetrant, potent and selective inhibitor of quinone reductase 2 (QR2)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Jean A Boutin et al.
Molecular pharmacology, 95(3), 269-285 (2018-12-21)
Quinone reductase 2 (QR2, E.C. 1.10.5.1) is an enzyme with a feature that has attracted attention for several decades: in standard conditions, instead of recognizing NAD(P)H as an electron donor, it recognizes putative metabolites of NADH, such as N-methyl- and
Charles-Etienne Benoit et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(38), 12690-12700 (2010-09-24)
High levels of reactive oxygen species (ROS) are associated with deficits in learning and memory with age as well as in Alzheimer's disease. Using DNA microarray, we demonstrated the overexpression of quinone reductase 2 (QR2) in the hippocampus in two
Dandan Chen et al.
Biology of reproduction, 97(4), 598-611 (2017-10-13)
NRH: quinone oxidoreductase 2 (NQO2) is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone to hydroquinones. Herein, we assessed the protein expression, subcellular localization, and possible functions of NQO2 in mouse oocyte meiotic maturation and
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