추천 제품
분석
≥98% (HPLC)
양식
powder
색상
white to gray
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
CCN(CC)C(OC(C=C1)=CC=C1C(NC2=C3C(C=CN3)=CC=C2)=O)=O
InChI
1S/C20H21N3O3/c1-3-23(4-2)20(25)26-16-10-8-15(9-11-16)19(24)22-17-7-5-6-14-12-13-21-18(14)17/h5-13,21H,3-4H2,1-2H3,(H,22,24)
InChI key
WCGIKJOMEYPSIP-UHFFFAOYSA-N
생화학적/생리학적 작용
NAB-14 is a negative allosteric modulator (NAM) selective for GluN2C/2D-containing NMDA glutamate receptors. NAB-14 was >800-fold selective for recombinant GluN2C/GluN2D over GluN2A/GluN2B in Xenopus oocytes and exhibited an IC50 value of 580 nM at recombinant GluN1/GluN2D receptors.
Negative allosteric modulator selective for GluN2C/2D-containing NMDA receptors
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Sharon A Swanger et al.
ACS chemical neuroscience, 9(2), 306-319 (2017-10-19)
N-Methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in numerous neurological disorders. NMDARs typically comprise two GluN1 and two GluN2 subunits. The four GluN2 subtypes (GluN2A-GluN2D) have distinct functional properties and gene
Lulu Yao et al.
Nature communications, 9(1), 4000-4000 (2018-10-03)
Selective disruption of synaptic drive to inhibitory neurons could contribute to the pathophysiology of various brain disorders. We have previously identified a GluN2A-selective positive allosteric modulator, GNE-8324, that selectively enhances N-methyl-D-aspartate receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory
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