SML2517
Tanshinone II-A sodium sulfonate
≥95%
동의어(들):
6,7,8,9,10,11-hexahydro-1,6,6-Trimethyl-10,11-dioxo-phenanthro[1,2-b]furan-2-sulfonic acid sodium salt, Sodium tanshinone IIA sulfonate, Sulfotanshinone sodium II-A, TIIAS
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C19H17NaO6S
CAS Number:
Molecular Weight:
396.39
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
분석
≥95%
양식
powder
색상
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
저장 온도
2-8°C
SMILES string
CC1(C)CCCC2=C3C(C(OC(S(=O)(O[Na])=O)=C4C)=C4C(C3=O)=O)=CC=C21
InChI
1S/C19H18O6S.Na/c1-9-13-15(20)16(21)14-10-5-4-8-19(2,3)12(10)7-6-11(14)17(13)25-18(9)26(22,23)24;/h6-7H,4-5,8H2,1-3H3,(H,22,23,24);/q;+1/p-1
InChI key
AZEZEAABTDXEHR-UHFFFAOYSA-M
생화학적/생리학적 작용
Tanshinone II A sulfonate is a water-soluble derivative of tanshinone II A that exhibits anti-inflammatory properties in rodent models of hepatitis and sepsis. Tanshinone II A sulfonate targets Ca2+-activated potassium channels and carboxylesterase 2. Recent studies indicate that tanshinone II A sulfonate but not tanshinone II A acts as potent negative allosteric modulator of the human purinergic receptor P2X7.
anti-inflammatory, potent negative allosteric modulator of the human purinergic receptor P2X7
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
M Kaiser et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 531-542 (2014-06-28)
Tanshinone II A sulfonate (TIIAS) was identified as a potent, selective blocker of purinergic receptor P2X7 in a compound library screen. In this study, a detailed characterization of the pharmacologic effects of TIIAS on P2X7 is provided. Because TIIAS is
Ruijuan Guan et al.
Frontiers in pharmacology, 9, 263-263 (2018-05-17)
Aberrant activation of hypoxia-inducible factor (HIF)-1α is frequently encountered and promotes oxidative stress and inflammation in chronic obstructive pulmonary disease (COPD). The present study investigated whether sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA, can mediate its
Jian Wang et al.
American journal of respiratory cell and molecular biology, 48(1), 125-134 (2012-10-16)
Danshen, the dried root of Salvia miltiorrhiza, is widely used in clinics in China for treating various diseases, including cardiovascular diseases. Sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA isolated as the major active component from Danshen
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.