SML1941
CGP3466B maleate salt
≥98% (HPLC)
동의어(들):
CGP 3466B, Dibenz[b,f]oxepin-10-methanamine, N-methyl-N-2-propyn-1-yl-, (2Z)-2-butenedioate (1:1), N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-methyl-N-(2-propynyl)amine monomaleic acid salt, Omigapil maleate salt, TCH346
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C19H17NO · C4H4O4
CAS Number:
Molecular Weight:
391.42
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
N(CC1=Cc2c(cccc2)Oc3c1cccc3)(CC#C)C.OC(=O)\C=C/C(=O)O
InChI
1S/C19H17NO.C4H4O4/c1-3-12-20(2)14-16-13-15-8-4-6-10-18(15)21-19-11-7-5-9-17(16)19;5-3(6)1-2-4(7)8/h1,4-11,13H,12,14H2,2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
SQAZQLMBEHYFJA-BTJKTKAUSA-N
생화학적/생리학적 작용
CGP3466B, also known as Omigapil maleate and TCH346, is a potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). It has been shown to have neuroprotective activity and received U.S. FDA Fast Track Designation for the treatment of congenital muscular dystrophy in May 2016.
Inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), neuroprotective.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Qing Yu et al.
PloS one, 8(6), e65468-e65468 (2013-06-14)
Congenital muscular dystrophy is a distinct group of diseases presenting with weakness in infancy or childhood and no current therapy. One form, MDC1A, is the result of laminin alpha-2 deficiency and results in significant weakness, respiratory insufficiency and early death.
Prasun Guha et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(5), 1417-1422 (2016-01-21)
Cocaine exerts its behavioral stimulant effects by facilitating synaptic actions of neurotransmitters such as dopamine and serotonin. It is also neurotoxic and broadly cytotoxic, leading to overdose deaths. We demonstrate that the cytotoxic actions of cocaine reflect selective enhancement of
Natasha T Snider et al.
PloS one, 11(8), e0160982-e0160982 (2016-08-12)
The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) signals during cellular stress via several post-translational modifications that change its folding properties, protein-protein interactions and sub-cellular localization. We examined GAPDH properties in acute mouse liver injury due to ethanol and/or acetaminophen (APAP) treatment.
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