SML1918

ML349

≥98% (HPLC)

• 동의어(들): ML349, (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone, ML 349, ML-349, (5,5-Dioxo-4H-thieno[4,5-c]thiochromen-2-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone
• 실험식(Hill 표기법): C₂₃H₂₂N₂O₄S₂
• CAS Number: 890819-86-0
• Molecular Weight: 454.56
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 3 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• SMILES string: [S]1(=O)(=O)Cc2c([s]c(c2)C(=O)N4CCN(CC4)c5ccc(cc5)OC)c3c1cccc3
• InChI: 1S/C23H22N2O4S2/c1-29-18-8-6-17(7-9-18)24-10-12-25(13-11-24)23(26)20-14-16-15-31(27,28)21-5-3-2-4-19(21)22(16)30-20/h2-9,14H,10-13,15H2,1H3
• InChI key: YVIJPELUPZUEJX-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

ML349 is a substrate-competitive, reversible and APT2-selective acyl-protein thioesterase (APT) inhibitor (IC₅₀/K_i = 510 nM/230 nM against APT2; IC₅₀ & K_i >10 μM against APT1). ML349 effectively inhibits cellular APT2 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT1. ML349 treatment (5 μM) is shown to restore palmitoylation and membrane localization of the multidomain scaffolding protein Scribble (Scrib) in MDCK cells overexpressing the epithelial-to-mesenchymal transcription factor (EMT-TF) Snail.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable