SML1823
Vosaroxin hydrochloride
≥98% (HPLC)
동의어(들):
1,4-Dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid hydrochloride, SNS-595 hydrochloride, Voreloxin hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C18H19N5O4S · HCl
CAS Number:
Molecular Weight:
437.90
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
광학 활성
[α]/D +42 to +52°, c = 1 in 0.1 M NaOH
색상
white to beige
solubility
H2O: 1 mg/mL, clear (warmed)
저장 온도
−20°C
SMILES string
O=C(C(C(O)=O)=C1)C2=C(N=C(C=C2)N3C[C@@H]([C@H](C3)NC)OC)N1C4=NC=CS4
InChI
1S/C18H19N5O4S.ClH/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18;/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26);1H/t12-,13-;/m0./s1
InChI key
JJZCCQHWCOXGCL-QNTKWALQSA-N
생화학적/생리학적 작용
Vosaroxin is an anti-cancer quinolone derivative that acts as a DNA intercalator and a topoisomerase II inhibitor, causing p53 independent tumor cell apoptosis. Vosaroxin stabilizes cleavage complexes formed by topoisomerase IIα and IIβ, which results in an accumulation of DNA double-strand breaks. Vosaroxin showed antineoplastic activity in multiple solid tumor and hematologic cancer cell lines and has been in clinical trials for AML.
Vosaroxin is an anti-cancer quinolone derivative that acts as a DNA intercalator and a topoisomerase II inhibitor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Gene C Jamieson et al.
Drugs, 76(13), 1245-1255 (2016-08-04)
Vosaroxin is a first-in-class anticancer quinolone derivative that targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to tumor cell apoptosis. Vosaroxin has chemical and pharmacologic characteristics distinct from other topoisomerase II inhibitors due to its quinolone scaffold.
Christopher B Benton et al.
Future oncology (London, England), 13(2), 125-133 (2016-09-13)
Vosaroxin is a quinolone compound that intercalates DNA and induces TP53-independent apoptosis, demonstrating activity against acute myeloid leukemia (AML) in Phase I-III trials. Here, we examine vosaroxin's mechanism of action and pharmacology, and we review its use in AML to
Nicholas J Short et al.
Expert review of hematology, 9(6), 529-534 (2016-05-10)
The outcomes of patients with relapsed or refractory acute myeloid leukemia (AML) are dismal, and effective treatment options in this patient population are therefore desperately needed. Vosaroxin is a first-in-class anticancer quinolone derivative that has shown promising activity in patients
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