SML1556

AEM1

≥98% (HPLC)

• 동의어(들): ARE expression modulator 1, N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine
• 실험식(Hill 표기법): C₂₀H₁₄FN₃O₂S
• CAS Number: 1030123-90-0
• Molecular Weight: 379.41
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to light brown
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: Fc1ccc(cc1)c2c3c([s]c2)[nH]cn[c]3=NCc4cc5c(cc4)OCO5
• InChI: 1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24)
• InChI key: QGYLTGSHWIGJJD-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

AEM1 (ARE expression modulator 1) is also a selective inhibitor of sirtuin 2, which is a protein deacetylase mediated by NAD⁺. Sirtuin 2 supports tumor cell proliferation, thus its inhibition stimulates cell death in tumors.

AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity.

AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity. AEM1 broadly decreases the expression of NRF2 controlled genes and sensitizes A549 cells to various chemotherapeutic agents.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable