SML1357

VU0453379 hydrochloride

≥98% (HPLC)

• 동의어(들): (S)2-CyclopentylN((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro1Hpyrrido[3,4b]indole-4-carboxamide hydrochloride
• 실험식(Hill 표기법): C₂₆H₃₄N₄O₂ · HCl
• CAS Number: 1638646-27-1
• Molecular Weight: 471.03
• MDL number: MFCD28987471
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329825812
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 20 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: CN1C2=C(C(C(NC[C@@H]3CCCN3C(C)C)=O)=CN(C4CCCC4)C2=O)C5=CC=CC=C51.Cl
• InChI: 1S/C26H34N4O2.ClH/c1-17(2)29-14-8-11-19(29)15-27-25(31)21-16-30(18-9-4-5-10-18)26(32)24-23(21)20-12-6-7-13-22(20)28(24)3;/h6-7,12-13,16-19H,4-5,8-11,14-15H2,1-3H3,(H,27,31);1H/t19-;/m0./s1
• InChI key: OCMGNMGYQPPMFF-FYZYNONXSA-N

설명

생화학적/생리학적 작용

VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC₅₀ = 1.3 μ,M, 59.2% GLP-1 max. VU0453379 potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets. In a model of Parkinson′s disease it showed a significant reversal of haloperidol-induced catalepsy at 30 mg/kg.

VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable