SML0990

JW651

≥98% (HPLC)

• 동의어(들): 1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate
• 실험식(Hill 표기법): C₂₁H₁₈Cl₂F₆N₂O₂
• CAS Number: 1438416-22-8
• Molecular Weight: 515.28
• MDL number: MFCD28137685
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825626
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 10 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: ClC1=CC=C(C(C2=CC=C(Cl)C=C2)N3CCN(C(OC(C(F)(F)F)C(F)(F)F)=O)CC3)C=C1
• InChI: 1S/C21H18Cl2F6N2O2/c22-15-5-1-13(2-6-15)17(14-3-7-16(23)8-4-14)30-9-11-31(12-10-30)19(32)33-18(20(24,25)26)21(27,28)29/h1-8,17-18H,9-12H2
• InChI key: UPIHQFKOCOKGEO-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

JW651 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). JW651 inhibited mouse MAGL with an IC₅₀ ~38 nM compared to 10,380 for ABHD6, a serine hydrolase that acts as an alternative hydrolase of 2-AG and >100,000 for FAAH, the hydrolase that degrades the endocannabinoid anandamide (AEA). JW651 was used as the MAGL inhibitor along with JW912, a fluorescent inihibitor of both MAGL and ABHD6.

JW651 is a potent selective inhibitor of MAGL; active in vivo.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable