SML0704

1-Methylnicotinamide chloride

≥98% (HPLC)

• 동의어(들): 3-Carbamyl-1-methylpyridinium chloride, MNA, N-Methylnicotinic acid amide chloride, N1-Methylnicotinamide chloride
• 실험식(Hill 표기법): C₇H₉ClN₂O
• CAS Number: 1005-24-9
• Molecular Weight: 172.61
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: H₂O: 15 mg/mL, clear
• 저장 온도: room temp
• SMILES string: Cl.[n+]1(cc(ccc1)C(=N)[O-])C
• InChI: 1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
• InChI key: BWVDQVQUNNBTLK-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide with antithrombotic and anti-inflammatory effects.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable