SML0222

TVP1022

≥98% (HPLC)

• 동의어(들): (1S)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine, (S)-Rasagiline, S-(-)-N-Propargyl-1-aminoindan
• 실험식(Hill 표기법): C₁₂H₁₃N
• CAS Number: 185517-74-2
• Molecular Weight: 171.24
• MDL number: MFCD09029306
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825241
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: (Powder, Film or Oil)
• solubility: DMSO: ≥15 mg/mL
• 저장 온도: 2-8°C
• SMILES string: C#CCN[C@H]1CCc2ccccc12
• InChI: 1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m0/s1
• InChI key: RUOKEQAAGRXIBM-LBPRGKRZSA-N

설명

생화학적/생리학적 작용

TVP1022 is an S-isomer of rasagiline, a PKC Pathway activator and neuroprotective and cytoprotective

TVP1022, the S-isomer of rasagiline, an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor. TVP1022, a neuroprotective and cytoprotective molecule, is also cardioprotective in rat models. Its activity is believed to involve stabilization of mitochondrial membrane potential, induction of Bcl-2 and activation of the PKC signalling pathway, enhancing the phosphorylation of protein kinase C and glycogen synthase kinase-3β.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H400
• 예방조치 성명서: P273 - P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable