SML0035

Tiagabine hydrochloride

≥98% (HPLC)

• 동의어(들): (-)-(R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride, (3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid hydrochloride
• 실험식(Hill 표기법): C₂₀H₂₅NO₂S₂ · HCl
• CAS Number: 145821-59-6
• Molecular Weight: 412.01
• MDL number: MFCD07369025
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825105
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 광학 활성: [α]/D -9 to -12°, c = 1 in H₂O
• 색상: white to beige
• solubility: H₂O: 10 mg/mL, clear
• 주관자: Cephalon
• 저장 온도: 2-8°C
• SMILES string: Cl.Cc1ccsc1C(=CCCN2CCC[C@H](C2)C(O)=O)c3sccc3C
• InChI: 1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1
• InChI key: YUKARLAABCGMCN-PKLMIRHRSA-N
• 유전자 정보: human ... SLC6A1(6529)

설명

애플리케이션

Tiagabine hydrochloride was used to study serotoninergic transmission in G1 cells. It has also been used to study its anti-aging effects on the sensory neurons of C. elegans.

생화학적/생리학적 작용

Selective inhibitor of the synaptic GABA transporter GAT1; Anticonvulsant

Tiagabine hydrochloride is an anticonvulsant and selective GABA reuptake inhibitor through inhibition of the synaptic GABA transporter GAT1.

Tiagabine increases the synaptic GABA and enhances the neuronal inhibition. It is effective as adjunctive treatment of epilepsy and anxiety disorders.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABA Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Cephalon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable