SBR00096

Lefamulin

≥98% (HPLC), powder

• 동의어(들): BC-3781
• 실험식(Hill 표기법): C₂₈H₄₅NO₅S
• CAS Number: 1061337-51-6
• Molecular Weight: 507.73
• UNSPSC 코드: 51101500

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria
• 동작 모드: protein synthesis | inhibits
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CSC4CCC(CC4O)N)C
• InChI: 1S/C28H45NO5S/c1-6-26(4)14-22(34-23(32)15-35-21-8-7-18(29)13-20(21)31)27(5)16(2)9-11-28(17(3)25(26)33)12-10-19(30)24(27)28/h6,16-18,20-22,24-25,31,33H,1,7-15,29H2,2-5H3/t16-,17+,18-,20-,21-,22-,24+,25+,26-,27+,28+/m1/s1
• InChI key: KPVIXBKIJXZQJX-FCEONZPQSA-N

설명

일반 설명

Lefamulin is an antibiotic which belongs to a class of coumpounds known as pleuromutilins. It is a semisynthetic derivative of the naturally occurring antibiotic pleuromutilin, and it is used for the treatment of bacterial infections.

생화학적/생리학적 작용

Lefamulin inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome. Specifically, it binds to the peptidyl transferase center of the ribosome and inhibits the transfer of amino acids to growing polypeptide chains, which leads to the inhibition of bacterial protein synthesis and bacterial death. Lefamulin is active against a wide range of Gram-positive bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA), as well as some atypical bacteria such as Legionella species. It has also been shown to have activity against some Gram-negative bacteria, including Haemophilus influenzae and Moraxella catarrhalis.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H371
• 예방조치 성명서: P260 - P264 - P270 - P308 + P311 - P405 - P501
• Hazard Classifications: STOT SE 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable