SBR00080

Dolutegravir

• 동의어(들): GSK 1349572
• 실험식(Hill 표기법): C₂₀H₁₉F₂N₃O₅
• CAS Number: 1051375-16-6
• Molecular Weight: 419.38
• UNSPSC 코드: 51101500

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: powder
• 색상: white to off-white
• 항생제 활성 스펙트럼: viruses
• 동작 모드: enzyme | inhibits
• 저장 온도: −20°C
• SMILES string: C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
• InChI: 1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1
• InChI key: RHWKPHLQXYSBKR-BMIGLBTASA-N

설명

일반 설명

Dolutegravir is an antibioitic which belongs to the class of compounds known as integrase strand transfer inhibitors (INSTIs).

생화학적/생리학적 작용

Dolutegravir inhibits HIV-1 viral replication, high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants. Dolutegravir inhibitis the action of the HIV integrase enzyme, which is necessary for the integration of viral DNA into the host genome, thereby preventing viral replication and reducing HIV viral load.

안전성 정보

• 픽토그램: GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H410
• 예방조치 성명서: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable