SBR00076

Baricitinib

≥98% (HPLC), powder

• 동의어(들): INCB 028050, LY 3009104
• 실험식(Hill 표기법): C₁₆H₁₇N₇O₂S
• CAS Number: 1187594-09-7
• Molecular Weight: 371.42
• UNSPSC 코드: 51101500

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: off-white
• 동작 모드: enzyme | inhibits
• 저장 온도: 2-8°C
• SMILES string: CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
• InChI: InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
• InChI key: XUZMWHLSFXCVMG-UHFFFAOYSA-N

설명

일반 설명

Baricitinib is an antibiotic which belongs to a class of compound called known as Janus kinase (JAK) inhibitors. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways.

애플리케이션

Baricitinib has been studied for its ability to inhibit Janus kinases (JAKs), which play a crucial role in the signaling pathways involved in inflammation and immune responses. JAK inhibitors like Baricitinib have potential applications in the treatment of a variety of autoimmune and inflammatory diseases.

생화학적/생리학적 작용

Baricitinib inhibits the activity of JAK enzymes, which are involved in cytokine signaling, leading to the suppression of inflammation and immune activation. Specifically, baricitinib inhibits JAK1 and JAK2 enzymes, which are associated with the signaling of different cytokines such as interleukin-6 (IL-6), interferon gamma (IFN-gamma), and granulocyte-macrophage colony-stimulating factor (GM-CSF). By inhibiting JAK enzymes, baricitinib reduces the activity of these cytokines and suppresses inflammation and immune activation.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H335,H360FD,H372
• 예방조치 성명서: P202 - P260 - P264 - P271 - P280 - P308 + P313
• Hazard Classifications: Repr. 1B - STOT RE 1 - STOT SE 3
• 표적 기관: Blood,Bone marrow,lymphatic system, Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable