SAB6010057

Anti-phospho-ERN1 (S724) antibody, clone 1F12, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• 동의어(들): Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, hIRE1p, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, Endoribonuclease, ERN1
• UNSPSC 코드: 12352203

속성

• 재조합: expressed in HEK 293 F cells
• Quality Level: 100
• 결합: unconjugated
• 항체 생산 유형: primary antibodies
• 클론: 1F12, recombinant monoclonal
• 양식: liquid
• 분자량: 150 kDa
• 정제법: affinity chromatography
• 종 반응성: human
• 농도: 0.6mg/ml
• 기술: ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• 동형: IgG
• UniProt 수납 번호: O75460
• 배송 상태: wet ice
• 저장 온도: -10 to -25°C
• 타겟 번역 후 변형: phosphorylation (pSer724)

설명

일반 설명

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:9637683, PubMed:11175748, PubMed:12637535). The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis (PubMed:24508390).

면역원

A synthesized peptide derived from human Phospho-ERN1 (S724)

서열

GRH-pS-FSR

물리적 형태

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

저장 및 안정성

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable