추천 제품
제품명
Anti-Actin-pan antibody produced in rabbit, affinity isolated antibody
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 41 kDa
종 반응성
rat, mouse, human
농도
~1 mg/mL
기술
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... ACTA1(58)
일반 설명
Anti-Actin-pan antibody detects endogenous levels of total actin-pan protein.
The ACTA1 (actin, α1) gene is mapped to human chromosome 1q42.13. The gene codes for actin 1, a thin filament component of skeletal muscle.
면역원
The antiserum was produced against synthesized peptide derived from human Actin.
Immunogen Range: 21-70
Immunogen Range: 21-70
생화학적/생리학적 작용
Mutations in ACTA1 (actin, α1) is known to cause thin filament myopathy, such as nemaline myopathy, congenital myopathy, actin myopathy, intranuclear rod myopathy, cap myopathy and core myopathy. Upregulation of the gene is observed in orthotopic liver transplantation without any earlier evidence of autoimmune liver disease. The encoded protein actin forms a network of filaments and is responsible for the shape of the cell. It provides cellular strength and promotes active movement of the cell.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments.
Hansen SD and Mullins RD
eLife, 4, 1-29 (2015)
Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases.
Pellegrini L
BioMed Research International, 2017, 1-7 (2017)
Severe congenital actin related myopathy with myofibrillar myopathy features.
Selcen D
Neuromuscular Disorders, 25(6), 488-492 (2015)
Mutation-specific effects on thin filament length in thin filament myopathy.
Winter JM
Annals of Neurology, 79(6), 959-969 (2016)
A Mutation in the ACTA1 gene Manifesting Nemaline Myopathy with Central Nervous System Lesions.
Ueda K
Journal of clinical neurology (Seoul, Korea), 13(3), 300-302 (2017)
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