SAB4501323

Anti-GRM5 antibody produced in rabbit

affinity isolated antibody

• 동의어(들): GPRC1E, GRM5, MGLUR5, Metabotropic glutamate receptor 5, mGluR5
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen 132 kDa
• 종 반응성: mouse, rat, human
• 농도: ~1 mg/mL
• 기술: ELISA: 1:10000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• NCBI 수납 번호: P41594
• UniProt 수납 번호: P41594
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... GRM5(2915)

설명

일반 설명

Glutamate metabotropic receptor 5 (GRM5)/metabotropic glutamate receptor subtype 5 (mGluR5) is a seven-transmembrane G-protein-coupled protein. It contains two binding sites and a structural connection to the N-methyl-D-aspartate receptor (NMDA) through a scaffold protein chain. GRM5 gene is located on human chromosome 11q14.2. Anti-GRM5 antibody detects endogenous levels of total GRM5 protein.

면역원

The antiserum was produced against synthesized peptide derived from human GRM5.

Immunogen Range: 21-70

생화학적/생리학적 작용

Glutamate metabotropic receptor 5 (GRM5) protein participates in glutamate signaling, supporting the action of natural stimuli, the excitability of N-methyl-D-aspartate receptor (NMDA) receptor, and abnormal synaptic plasticity in addiction. It is important for the pathophysiology and to treat eating disorders. It controls the developmental variation dependent on glutamate. It also plays a key role in adaptive synaptic plasticity, long-term potentiation, and learning. The pharmacological inhibitors of mGlu5 may have a therapeutic possibility in Bulimia nervosa (BN). Absence of mGluR5 plays a pathogenic role in autism spectrum disorder (ASD).

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable