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Merck
모든 사진(2)

주요 문서

SAB4501277

Sigma-Aldrich

Anti-GPR35 antibody produced in rabbit

affinity isolated antibody

동의어(들):

GPR35, Probable G-protein coupled receptor 35

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

분자량

antigen 34 kDa

종 반응성

human

농도

~1 mg/mL

기술

ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... GPR35(2859)

일반 설명

Anti-GPR35 Antibody detects endogenous levels of total GPR35 protein.

GPR35 (G protein-coupled receptor 35) is a lysophosphatidic acid receptor. It is highly expressed in the immune and gastrointestinal systems, dorsal root ganglia, cerebellum and brain. It is mapped to human chromosome 2q37.3 .

면역원

The antiserum was produced against synthesized peptide derived from human GPR35.

Immunogen Range: 51-100

생화학적/생리학적 작용

GPR35 (G protein-coupled receptor 35) is involved in heart failure and pain perception. It also participates in the formation of gastric cancer. It serves as a receptor for the kynurenine pathway intermediate kynurenic acid. It can also acts as an important lysophosphatidic acid receptor.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

GPR35 is a novel lysophosphatidic acid receptor
Oka S, et al.
Biochemical and Biophysical Research Communications, 395(2), 232-237 (2010)
Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells
Okumura S, et al.
Cancer Science, 95(2), 131-135 (2004)
GPR35 as a Novel Therapeutic Target
Mackenzie AE, et al.
Frontiers in Endocrinology, 2 (2011)
Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35
Wang J, et al.
The Journal of Biological Chemistry, 281(31), 22021-22028 (2006)
Crucial positively charged residues for ligand activation of the GPR35 receptor
Zhao P, et al.
The Journal of Biological Chemistry, 289(6), 3625-3638 (2014)

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