SAB4200657
Monoclonal Anti-EEF1A1 antibody produced in mouse
clone EF48, purified from hybridoma cell culture
동의어(들):
CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, eukaryotic translation elongation factor 1 α 1
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모든 사진(2)
About This Item
UNSPSC 코드:
12352203
NACRES:
NA.41
추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
EF48
양식
buffered aqueous solution
종 반응성
bovine, mouse, rat, human, monkey, canine
농도
~1 mg/mL
기술
immunoblotting: 1-2 μg/mL using whole extracts of HEK-293T cells.
immunofluorescence: 0.5-1 μg/mL using SW-620 cells.
동형
IgG2b
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... EEF1A1(1915)
mouse ... Eef1a1(13627)
rat ... Eef1a1(171361)
일반 설명
Eukaryotic translation elongation factor 1 α 1 (EEF1A1) is a cellular protein which is part of the eukaryotic elongation factor 1 (eEF1) complex. The gene encoding it is localized on human chromosome 6q14.1.
Monoclonal Anti-EEF1A1 (mouse IgG2b isotype) is derived from the hybridoma EF48 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Eukaryotic elongation factor 1 A-1 (EEF1A1), also known as EF-l α is a GTP-binding protein. EEF1A1 is one of the most abundant cytoplasmic proteins and is ubiquitously expressed except in neurons and muscle.
면역원
a synthetic peptide corresponding to an internal sequence of human EEF1A1
애플리케이션
Monoclonal Anti-EEF1A1 antibody produced in mouse has been used in immunoblotting and immunofluorescence.
생화학적/생리학적 작용
Eukaryotic elongation factor 1 A-1 (EEF1A1) is involved in proper codon-anticodon binding interactions between mRNAs and tRNAs at the tRNA acceptor site of the ribosome. EEF1A also plays a translation-independent role in embryogenesis, senescence, oncogenic transformation, cell proliferation, apoptosis, cytoskeletal organization and protein degradation. Overexpression of EEF1A1 has been observed in various tumors of the pancreas, colon, breast, lung, and stomach.
Eukaryotic translation elongation factor 1 α 1 (EEF1A1) binds to aminoacetylated tRNAs and delivers them to the elongating ribosome during protein synthesis. It aids in the association of the eukaryotic elongation factor 1 (eEF1) complex with the HIV-1 (human immunodeficiency virus-1) reverse transcription complex. EEF1A1 also associates with genomic RNA secondary structures of RNA viruses and helps in their replication.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Dinesh C Soares et al.
Biology direct, 8, 29-29 (2013-11-14)
This article was reviewed by Frank Eisenhaber and Ramanathan Sowdhamini.Translation elongation factors eEF1A1 and eEF1A2 are 92% identical but exhibit non-overlapping expression patterns. While the two proteins are predicted to have similar tertiary structures, it is notable that the minor
Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localized sites of sequence variation
Soares DC and Abbott CM
Biology Direct, 8(1), 29-29 (2013)
A Lamberti et al.
Amino acids, 26(4), 443-448 (2004-08-04)
An increasing number of evidences suggest the involvement of the eukaryotic elongation factor 1A, a core component of the protein synthesis machinery, at the onset of cell transformation. In fact, eEF1A is shown to be up-regulated in cell death; moreover
The ubiquitin-like protein FAT10 stabilizes eEF1A1 expression to promote tumor proliferation in a complex manner
Liu X, et al.
Cancer research, 76(16), 4897-4907 (2016)
Boris Negrutskii et al.
Expert review of proteomics, 9(1), 71-83 (2012-02-02)
Phosphoproteomics is often aimed at deciphering the modified components of signaling pathways in certain organisms, tissues and pathologies. Phosphorylation of housekeeping proteins, albeit important, usually attracts less attention. Here, we provide targeted analysis of eukaryotic translation elongation factor 1A (eEF1A)
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