생물학적 소스
rabbit
Quality Level
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
51896 Da
종 반응성
human, mouse
기술
flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... BECN1(8678)
관련 카테고리
일반 설명
Beclin 1 (BECN1) is a tumor suppressor gene. It is a 450 amino-acid protein having three domains. The gene encoding BECN1 is localized on human chromosome 17q21.
애플리케이션
ANTI-BECLIN1-BH3 DOMAIN antibody produced in rabbit has been used in Western blotting.
생화학적/생리학적 작용
Beclin 1 (BECN1) acts as an initiator of autophagy and is vital in the early stages of autophagosome formation. It has a role in various tumors and cancers. BECN1 is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking.
물리적 형태
Supplied in PBS with 0.09% (W/V) sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
RNF146 Inhibits Excessive Autophagy by Modulating the Wnt-?-Catenin Pathway in Glutamate Excitotoxicity Injury
Yuefan Yang
Frontiers in Cellular Neuroscience (2017)
Class III phosphoinositide 3-kinase?Beclin1 complex mediates the amino
acid-dependent regulation of autophagy in C2C12 myotubes
acid-dependent regulation of autophagy in C2C12 myotubes
BioChemistry: An Indian Journal (2003)
Decreased expression of Beclin-1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma.
Hu Z, et.al
Molecular Medicine Reports, 14(2), 1567-1573 (2016)
The BECN1 N-terminal domain is intrinsically disordered.
Lee EF
Autophagy, 12(3), 460-471 (2016)
Polyglutamine tracts regulate beclin 1-dependent autophagy.
Ashkenazi A, et al.
Nature, 545, 108-111 (2017)
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