SAB1306481

ANTI-CD45(C-TERMINAL) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 동의어(들): CD45, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: IgG fraction of antiserum
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: 147254 Da
• 종 반응성: human
• 기술: flow cytometry: 1:10-1:50; immunohistochemistry: 1:10-1:50; western blot: 1:1000
• NCBI 수납 번호: NP_002829.3
• UniProt 수납 번호: P08575
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PTPRC(5788)

설명

일반 설명

Protein tyrosine phosphatase, receptor type C (PTPRC) or leucocyte common antigen CD45 is expressed on T-cells and is found in multiple isoforms. The extracellular domain of the protein is predicted to have an amino-terminal mucin-like segment, a cysteine-rich domain and three fibronectin type 3 domains. The gene encoding this protein is localized on human chromosome 1q31.3.

애플리케이션

ANTI-CD45(C-TERMINAL) antibody produced in rabbit has been used in Western blotting.

생화학적/생리학적 작용

Protein tyrosine phosphatase, receptor type C (PTPRC) or leucocyte common antigen CD45 acts as a protein tyrosine phosphatase in leucocyte signaling. It has a role in flow cytometric diagnostics in leukemia. By dephosphorylation of Src kinases, the protein acts as a regulator of antigen receptor signaling in T and B cells. As a negative regulator of janus kinases, CD45 inhibits cytokine receptor signaling.

물리적 형태

Supplied in PBS with 0.09% (W/V) sodium azide

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable