SAB1300430

Anti-MST3 (C-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 동의어(들): Anti-Mammalian STE20-like protein kinase 3, Anti-STE20-like kinase MST3, Anti-STK24, Anti-STK3, Anti-Serine/threonine protein kinase 24
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: IgG fraction of antiserum
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 종 반응성: human
• 기술: immunohistochemistry: 1:50-1:100; indirect ELISA: 1:1000; western blot: 1:100-1:500
• NCBI 수납 번호: NP_003567
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... MST3(8428)

설명

일반 설명

MST3 (mammalian sterile 20 (Ste20)-like kinase 3) gene is mapped to human chromosome 13q32.2. The gene is ubiquitously expressed in different tissues. MST3 belongs to the subfamily of the germinal centre kinase III kinases. It is also known as serine/threonine kinase 24 (STK24). The encoded protein contains a kinase domain and a regulatory domain at the N and C-terminal, respectively. The protein includes two isoforms namely MST3a and MST3b which differ by 12 amino acids. The protein is mostly localized in the cytoplasm.

The yeast ‘Sterile 20′ gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 [PubMed 10644707]).[supplied by OMIM]

면역원

MST3 (Q9Y6E0, 350-384)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MST3.

생화학적/생리학적 작용

MST3 (mammalian sterile 20 (Ste20)-like kinase 3) is known to be involved in the development of proper filopodia, dendritic spine, and excitatory synapse. MST3 induces outgrowth of axon and its regeneration in vivo. MST3 is associated with Caspase 3-mediated apoptosis in trophoblasts, induced by hypoxia.

물리적 형태

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable