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Merck
모든 사진(1)

주요 문서

S9549

Sigma-Aldrich

Superoxide dismutase–polyethylene glycol from bovine erythrocytes

lyophilized powder, ≥1,350 units/mg protein

동의어(들):

PEG-SOD

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About This Item

MDL number:
UNSPSC 코드:
12352204
NACRES:
NA.54

양식

lyophilized powder

Quality Level

특이 활성도

≥1,350 units/mg protein

분자량

5000 Da

구성

Protein, ≥20% biuret

라벨링 범위

≥10 mol PEG per mol protein

저장 온도

−20°C

일반 설명

Superoxide dismutase from bovine erythrocytes is a copper and zinc superoxide dismutase. Copper and zinc ions are coordinated by active site histidine residues. It has β-barrel structure.

애플리케이션

Superoxide dismutase-polyethylene glycol from bovine erythrocytes has been used:
  • in the incubation of lung slices for measurement of dihydroethidium (DHE) fluorescence in cultured bovine pulmonary artery endothelial cells
  • as supplement in T cell culture to investigate its effect on cytokine production
  • in the preincubation of the carotid artery sections prior to DHE treatment

생화학적/생리학적 작용

Superoxide dismutase-polyethylene glycol (SOD-PEG) is effective than SOD in scavenging free radicals in injuries. It reduces oxidative damage in ovarian follicles cell culture and during ovarian tissue transplantation. SOD-PEG is also effective in scavenging superoxide in mitochondrial abnormalities.

포장

Package size based on protein content

기타 정보

Superoxide dismutase from bovine erythrocytes coupled to methoxy-polyethylene glycol, M.W. 5,000, through secondary amine linkage.

물리적 형태

Lyophilized powder containing PEG plus 5% citrate buffer salts

제조 메모

Enzyme derived

픽토그램

Health hazard

신호어

Danger

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Resp. Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia
Dayal S, et al.
PLoS ONE, 12(4), e0175732-e0175732 (2017)
Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation
Chen W, et al.
The Journal of Biological Chemistry, 286, 13846-13851 (2011)
Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity.
Yi X, Yuan D, Farr SA, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 191, 34-46 (2014)
Roles of zinc and copper in modulating the oxidative refolding of bovine copper, zinc superoxide dismutase
Li HT, et al.
Acta biochimica et biophysica Sinica, 42(3), 183-194 (2010)
The beneficial effects of polyethylene glycol-superoxide dismutase on ovarian tissue culture and transplantation
Kim EJ, et al.
Journal of Assisted Reproduction and Genetics, 32(10), 1561-1569 (2015)

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