S8010

(±)-Sulpiride

• 동의어(들): (±)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, (±)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide
• 실험식(Hill 표기법): C₁₅H₂₃N₃O₄S
• CAS Number: 15676-16-1
• Molecular Weight: 341.43
• EC Number: 239-753-7
• MDL number: MFCD00055061
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277933
• NACRES: NA.77

속성

• 양식: powder
• Quality Level: 100
• 색상: white
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL; 0.1 M HCl: soluble; H₂O: slightly soluble; ethanol: soluble
• 주관자: Sanofi Aventis
• 저장 온도: 2-8°C
• SMILES string: CCN1CCCC1CNC(=O)c2cc(ccc2OC)S(N)(=O)=O
• InChI: 1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
• InChI key: BGRJTUBHPOOWDU-UHFFFAOYSA-N
• 유전자 정보: human ... CA1(759) , CA2(760) , CA4(762) , CA5A(763) , CA5B(11238) , CA9(768) , DRD2(1813)

설명

애플리케이션

(±)-Sulpiride was used to study the effect of dopamine D₂ receptor signaling on calcium channels in rat pituitary melanotropic cells.⁴⁷

생화학적/생리학적 작용

(±)-Sulpiride is a D₂ dopamine antagonist and an effective treatment for schizophrenia when used in combination with clozapine, a relatively weak D₂-dopaminergic antagonist. It is an antipsychotic agent and also exhibits neuroleptic properties but poorly penetrates the central nervous system.^45,46

특징 및 장점

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

재구성

Solutions may be stored for several days at 4 °C.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable