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Merck
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주요 문서

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S5321

Sigma-Aldrich

S15535

≥98% (HPLC), solid

동의어(들):

1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C21H24N2O2
CAS Number:
146998-34-7
Molecular Weight:
336.43
MDL number:
MFCD00911672
UNSPSC 코드:
12352200
PubChem Substance ID:
329824452
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

solid

색상

white

solubility

DMSO: ~6 mg/mL
H2O: insoluble

저장 온도

2-8°C

SMILES string

C1COc2c(O1)cccc2N3CCN(CC3)C4Cc5ccccc5C4

InChI

1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-21(19)25-13-12-24-20/h1-7,18H,8-15H2

InChI key

QJPPEMXOOWNICQ-UHFFFAOYSA-N

애플리케이션

S15535 has been used as a serotonin 1A receptor (5-HT1A) agonist in zebrafish.
S15535 may be used in histamine 5-HT1A-medaited cell signaling studies.

생화학적/생리학적 작용

Potent, orally active, partial 5-HT1A receptor agonist
S15535, a benzodioxane, is a selective but partial agonist of histamine serotonin 1A (5-HT1A) receptor. It activates presynaptic 5-HT1A receptors and suppresses the release of hippocampal 5-HT. It acts as an anxiolytic agent and modulates the cholinergic and cognitive function in rodents.

픽토그램

Environment
GHS09

신호어

Warning

유해 및 위험 성명서

H410

예방조치 성명서

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
016K46151
017K4619
017K4609
016K4615

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COA 검색

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문서 라이브러리 방문

M J Millan et al.
The Journal of pharmacology and experimental therapeutics, 282(1), 148-161 (1997-07-01)
In these studies, we characterized the influence of the novel benzodioxopiperazine serotonin (5-HT)1A ligand, S 15535, on the release of 5-HT in rat hippocampus and compared its potential anxiolytic properties with those of the 5-HT1A receptor partial agonist, buspirone, the
F Lejeune et al.
Synapse (New York, N.Y.), 30(2), 172-180 (1998-09-02)
This study examined the influence of the highly selective 5-HT1A receptor ligands, flesinoxan, S 15535, and WAY 100,635, upon the electrical activity of dopaminergic neurons in the ventral tegmental area (VTA), as compared to serotonergic neurons in the dorsal raphe
M J Millan et al.
The Journal of pharmacology and experimental therapeutics, 282(1), 132-147 (1997-07-01)
The novel, potential anxiolytic, S 15535 (4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine), is an agonist and antagonist (weak partial agonist) at pre- and postsynaptic serotonin (5-HT)1A receptors, respectively. Herein, we characterized its influence on dialysate levels of 5-HT, dopamine (DA) and NAD simultaneously determined in
B J van der Vegt et al.
Physiology & behavior, 74(1-2), 205-211 (2001-09-21)
Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of postsynaptic serotonin-1A (5-HT(1A))
Jasmin M Dao et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(7), 1319-1331 (2011-03-18)
Epidemiological studies have shown that adolescent smoking is associated with health risk behaviors, including high-risk sexual activity and illicit drug use. Using rat as an animal model, we evaluated the behavioral and biochemical effects of a 4-day, low-dose nicotine pretreatment
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