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Merck
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주요 문서

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S3445

Sigma-Aldrich

SM-19712 hydrate

≥98% (HPLC)

동의어(들):

4-Chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl]benzenesulfonamide sodium salt hydrate

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C18H13ClN5NaO3S · xH2O
CAS Number:
194542-56-8
Molecular Weight:
437.84 (anhydrous basis)
MDL number:
MFCD06798351
UNSPSC 코드:
12352200
PubChem Substance ID:
329824532
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

색상

off-white to light brown

solubility

DMSO: ≥20 mg/mL
H2O: ≥20 mg/mL

저장 온도

2-8°C

SMILES string

ClC1=CC=C(S(N(C(NC2=C(C#N)C(C)=NN2C3=CC=CC=C3)=O)[Na])(=O)=O)C=C1

InChI

1S/C12H10ClN5O3S.Na.H2O/c1-7-10(6-14)11(17-16-7)15-12(19)18-22(20,21)9-4-2-8(13)3-5-9;;/h2-5H,1H3,(H3,15,16,17,18,19);;1H2/q;+1;/p-1

InChI key

HLHPDQXMLDUDQV-UHFFFAOYSA-M

관련 카테고리

애플리케이션

SM-19712 hydrate was used in studies to determine the effectiveness of ECE inhibition as a treatment option for Alzheimer′s disease.

생화학적/생리학적 작용

Nonpeptide, potent and selective endothelin converting enzyme inhibitor.
SM-19712 a sulfonylureid-pyrazole derivative is a potent and selective inhibitor of endothelin converting enzyme (ECE). It attenuates the effects of ischemic acute renal failure and reduces the inflammation, tissue injury and vasoconstriction induced by dextran sodium sulfate in mouse colon.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
070M4620V
094K4605

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문서 라이브러리 방문

Seungjun Lee et al.
Inflammatory bowel diseases, 15(7), 1007-1013 (2009-02-10)
Ingestion by mice of dextran sodium sulfate (DSS) induces colonic vasoconstriction and inflammation, with some of the effects potentially mediated by the vasoconstrictor endothelin-1 (ET-1). In this study, mice given 5% 40 kD DSS for 5-6 days had elevated colonic
Y Matsumura et al.
Japanese journal of pharmacology, 84(1), 16-24 (2000-10-24)
Effects of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl- 1-1-phenyl- 1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt), a novel endothelin converting enzyme (ECE) inhibitor, on ischemic acute renal failure (ARF) in rats were examined in comparison with those of phosphoramidon, a conventional ECE inhibitor. ARF was induced by
Niki C Carty et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 16(9), 1580-1586 (2008-07-31)
Reduction of Abeta deposition is a major therapeutic strategy in Alzheimer's disease (AD). The concentration of Abeta in the brain is modulated not only by Abeta production but also by its degradation. One of the proteases involved in the degradation
K Umekawa et al.
Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other

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