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Merck
모든 사진(4)

주요 문서

S0375

Sigma-Aldrich

D-Saccharic acid 1,4-lactone monohydrate

≥98.0% (HPLC)

동의어(들):

D-Glucaric acid-1,4-lactone, D-Saccharolactone

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About This Item

실험식(Hill 표기법):
C6H8O7 · H2O
CAS Number:
Molecular Weight:
210.14
Beilstein:
85594
MDL number:
UNSPSC 코드:
12352201
PubChem Substance ID:
NACRES:
NA.25

Quality Level

분석

≥98.0% (HPLC)

양식

powder

불순물

≤10.0% water (Karl Fischer)

색상

white

mp

91 - 93 °C ((196 - 199 °F ))

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

저장 온도

2-8°C

SMILES string

O.O[C@@H]1[C@@H](O)C(=O)O[C@@H]1[C@H](O)C(O)=O

InChI

1S/C6H8O7.H2O/c7-1-2(8)6(12)13-4(1)3(9)5(10)11;/h1-4,7-9H,(H,10,11);1H2/t1-,2-,3+,4+;/m1./s1

InChI key

NPFKVZHSFSFLPU-QGBSHYGGSA-N

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일반 설명

D-Saccharic acid 1,4-lactone monohydrate (DSAL) has an ability to inhibit the activity of β-glucuronidase enzyme.It also potentially inhibits Klotho deglycosylation of excitatory amino acid transporters (EAATs) and peptide transporters (PEPTs).

애플리케이션

D-Saccharic acid 1,4-lactone monohydrate has been used as a constituent of phosphate buffer to block incidental β-glucuronidase activity in Streptococcus pneumoniae hyaluronan lyase (SpnHL) activity assay. It has also been used as a component of reaction mixture in Iduronidase activity assay and UDP-glucuronosyltransferase 1 (UGT1A1) inhibition assay.

기타 정보

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

Syed Ahmad et al.
Current chemical genomics, 5, 13-20 (2011-06-07)
CPT-11 is a widely-used anti-cancer drug that is converted in vivo to its active metabolite, SN-38. In the liver, enzymes detoxify SN-38 by coupling it to a glucuronidate moiety and this inactive compound (SN-38G) is excreted into the gastrointestinal tract.
beta-Klotho as a Negative Regulator of the Peptide Transporters PEPT1 and PEPT2
Abousaab A, et al.
Cellular Physiology and Biochemistry, 40(5), 874-882 (2016)
Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice
Wang D, et al.
Nature Biotechnology, 36(9), 839-839 (2018)
In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia
Chiou W, et al.
Xenobiotica, 44(3), 276-282 (2014)
Magnetic macroporous bead cellulose functionalised with recombinant hyaluronan lyase for controllable hyaluronan fragmentation
Kavsparova J, et al.
Process Biochemistry (Oxford, United Kingdom), 72, 105-111 (2018)

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