추천 제품
생물학적 소스
plant (Silybum marianum)
Quality Level
양식
powder
기술
toxicology assay: suitable
응용 분야
microbiology
저장 온도
−20°C
SMILES string
O1C(C(Oc3c1ccc(c3)C4Oc5c(c(cc(c5)O)O)C(=O)C4O)c2cc(c(cc2)O)OC)CO
InChI
1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
InChI key
SEBFKMXJBCUCAI-UHFFFAOYSA-N
일반 설명
Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.
애플리케이션
Silymarin has been used to study:
- its in vitro antiviral, antibacterial, antifungal activities and cytotoxicity
- its effect of silymarin on bladder contractions in cyclophosphamide (CYP)-induced cystitis rat model
- its effect on liver toxication induced by Fumonisin B1 in mice
생화학적/생리학적 작용
Silymarin is originally known to protect liver from various toxic agents and is used in treating hepatitis and cirrhosis. Silymarin possesses many biological actions such as antifibrotic, anti-lipid peroxidative, anti-inflammatory, immunomodulatory and membrane stabilizing. Silymarin also aids in liver regeneration.
Silymarin provides cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.
Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin.
기타 정보
Mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
Chun-Ping Lu et al.
Chemico-biological interactions, 290, 12-18 (2018-05-14)
Macrophages and inflammasome pathway are involved in high-glucose toxicity and development of insulin resistance. Silymarin (SMR) was known to modulate glucose homeostasis and reduce inflammation. However, it is still unknown whether SMR possess anti-hyperglycemic effects in diabetic-like knockout mice (Hnf-1αkin/-/Ins.cre
Silymarin Restores Regulatory T Cells (Tregs) Function in Multiple Sclerosis (MS) Patients In Vitro.
Maryam Shariati et al.
Inflammation, 42(4), 1203-1214 (2019-02-27)
Dysregulation of the immune system and impairment in the function and number of patient-derived regulatory T cells (Treg) have an important role in multiple sclerosis (MS) pathogenesis. MS patients still receive different medications to overcome the relapses and to slow
Verônica de Souza Santos et al.
Life sciences, 228, 305-315 (2019-05-03)
Silymarin, an extract from Silybum marianum (milk thistle) containing a standardized mixture of flavonolignans that ameliorates some types of liver disease and, more recently, kidney damage, could be used for the ROS-scavenging effect of these antioxidants. Furthermore, contrast-induced nephropathy (CIN)
Vieri Piazzini et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-06)
Two novel nanomicellar formulations were developed to improve the poor aqueous solubility and the oral absorption of silymarin. Polymeric nanomicelles made of Soluplus and mixed nanomicelles combining Soluplus with d-α-tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS) were prepared using
Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals.
Eminzade, S.
Nutrition & Metabolism, 5, 18-18 (2008)
문서
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.