RAB0441

Phospho-Stat1 (pSer⁷²⁷) and pan-Stat1 ELISA Kit

for detection of phospho-stat1 (pSer⁷²⁷) and pan-stat1 in human or mouse cell and tissue lysates

• UNSPSC 코드: 41116158
• NACRES: NA.32

속성

• 종 반응성: mouse, human
• 기술: ELISA: suitable; capture ELISA: suitable
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... STAT1(6772) ; mouse ... STAT1(20846)

설명

일반 설명

The Phospho-Stat1 (pSer⁷²⁷) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.

면역원

Stat1 (pTyr⁷²⁷) synthetic phosphopeptide, Recombinant Human STAT1

애플리케이션

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

생화학적/생리학적 작용

Signal transducer and activator of transcription 1 (STAT1) undergoes phosphorylation on serine-727. This Phospho-Stat1 regulates pro- and anti-apoptotic genes following several stress-induced responses. STAT-1 interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT-1 is an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumour suppressor. STAT-1 functions as a pro-apoptotic factor in cardiac myocytes, brain or liver exposed to ischaemia–reperfusion injury. Thus, inhibition of STAT-1-activated pathway by epigallocatechin-3-gallate (EGCG), can be considered as a potential therapeutic method against ischaemic tissue injury. Repression of STAT-1 expression by human papillomavirus (HPV) oncoproteins E6 and E7 at transcription level is essential for genome amplification and maintenance of episomes, which is suggested to have a crucial role in viral pathogenesis.

안전성 정보

• 픽토그램: GHS05,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H290,H335
• Hazard Classifications: Met. Corr. 1 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 8A - Combustible corrosive hazardous materials