추천 제품
제품명
Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
생물학적 소스
Streptomyces hygroscopicus
Quality Level
vapor pressure
0.56 hPa ( 20 °C)
분석
≥95% (HPLC)
양식
solution
autoignition temp.
301 °C
농도
2.5 mg/mL in DMSO (2.74 mM)
색상
colorless to yellow
항생제 활성 스펙트럼
fungi
yeast
동작 모드
enzyme | inhibits
저장 온도
−20°C
일반 설명
Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
Rapamycin, an mTOR inhibitor, is derived from Streptomyces hygroscopicus. It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age.
애플리케이션
Rapamycin has been used:
- as a supplement in mTeSR1 medium to culture induced pluripotent stem cell (iPSC) colonies for induction of autophagy signaling
- to treat the Drosophila S2 cells at 65-70% confluence,
- to measure protein synthesis
- to stimulate autophagy in ovarian cancer cells
포장
200uL
기타 정보
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Is Hygroscopic.
Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Rapamycin probe summary on the Chemical Probes Portal website.
Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Rapamycin probe summary on the Chemical Probes Portal website.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
188.6 °F - closed cup
Flash Point (°C)
87 °C - closed cup
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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문서
Sigma-Aldrich offers many products related to phosphoinositide kinases for your research needs.
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