R8526

RO-52 (SSA) human

recombinant, expressed in E. coli, liquid

• 동의어(들): Anti-RO-52 antibody
• MDL number: MFCD03458409
• UNSPSC 코드: 12352202
• NACRES: NA.56

속성

• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in E. coli
• 양식: liquid
• 분자량: 52 kDa by SDS-PAGE
• 기술: ELISA: suitable
• UniProt 수납 번호: P19474
• 저장 온도: −70°C
• 유전자 정보: human ... TRIM21(6737)

설명

일반 설명

Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.

애플리케이션

RO-52 (SSA) human has been used:

• as a component of the autoantigen array
• to immobilise protein on the self-assembly monolayer
• in enzyme-linked immunosorbent assays (ELISAs)

생화학적/생리학적 작용

RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.

Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.

물리적 형태

solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable