R8407

Anti-RAB25 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-CATX-8
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen ~25 kDa
• 종 반응성: human
• 농도: ~1.0 mg/mL
• 기술: western blot: 1-2 μg/mL using whole extracts of human A431 cells
• UniProt 수납 번호: P57735
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... RAB25(57111)

설명

일반 설명

Ras-related protein Rab-25 (Rab25) is a member of the Rab family of small guanosine triphosphatases (GTPases). The Rab family belongs to the Ras superfamily of small GTPases. Rab25 is specifically expressed in epithelial cells and is localized on human chromosome 1q22. It comprises a GTPase tertiary structure with a central barrel with a six-stranded β-sheet surrounded by α-helices.

특이성

Anti-Rab25 recognizes human Rab25 (not tested in other species).

애플리케이션

Anti-RAB25 antibody produced in rabbit may be used in immunoblotting.

생화학적/생리학적 작용

Ras-related protein Rab-25 (Rab25) acts as an oncogene or a tumor suppressor gene. Overexpression of this gene is seen in several cancers such as ovarian cancer, bladder cancer, breast cancer, gastric cancer, liver cancer, non-small cell lung cancer, renal cancer, glioblastoma multiforme and prostate cancer. It helps to control the vesicle trafficking and signaling pathways. Rab25 is associated with the apical recycling system of epithelial cells. Antibodies to Rab proteins may serve as useful tools for studying subcellular localization and membrane organization.

물리적 형태

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

저장 및 안정성

Store at –20 °C. For continuous use, the product maybe stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.