PZ0345

PF-06700841 tosylate salt

≥98% (HPLC)

• 동의어(들): [(1S)-2,2-Difluorocyclopropyl][3-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-methanone tosylate salt
• 실험식(Hill 표기법): C₁₈H₂₁F₂N₇O · C₇H₈O₃S
• CAS Number: 1883299-62-4
• Molecular Weight: 561.60
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329823853
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• 저장 온도: room temp
• SMILES string: FC1(F)C[C@H]1C(N2[C@H]3CN(C4=CC=NC(NC5=CN(C)N=C5)=N4)C[C@@H]2CC3)=O.CC6=CC=C(S(=O)(O)=O)C=C6
• InChI key: FAKGOYNHHHOTEN-VDTKTRGNSA-N

설명

애플리케이션

PF-06700841 tosylate salt has been used as an inhibitor of Janus kinase1 (JAK1) to study its therapeutic effect on the adjuvant induced arthritis (AIA) rat model. It has also been used as an inhibitor of interferon-α/β receptor alpha chain (IFNAR1) signaling adaptor tyrosine kinase (2TYK2) in mice.

생화학적/생리학적 작용

PF-06700841 is an inhibitor of JAK1 and TYK2 kinases.

PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable