PZ0189

CP-316819

≥98% (HPLC)

• 동의어(들): 5-Chloro-N-[(1S,2R)-2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide; GPi 819
• 실험식(Hill 표기법): C₂₁H₂₂ClN₃O₄
• CAS Number: 186392-43-8
• Molecular Weight: 415.87
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329823763
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to tan
• solubility: DMSO: ≥20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: CON(C)C(=O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)c2cc3cc(Cl)ccc3[nH]2
• InChI: 1S/C21H22ClN3O4/c1-25(29-2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19+/m0/s1
• InChI key: WEQLRDLTRCEUHG-PKOBYXMFSA-N

설명

애플리케이션

CP-316819 has been used as a positive control to study the inhibitory activity against glycogen phosphorylase in vitro.

생화학적/생리학적 작용

CP-316819 belongs to the family of indole-2-carboxamide series of phosphorylase inhibitors. It has an ability to regulate interaction of glycogen targeting subunit (GL) 16mer peptide with phosphorylase a.

CP-316819 is a glycogen phosphorylase inhibitor

CP-316819 is a potent glycogen phosphorylase inhibitor. (IC50 = 40 nM against human liver GPα.) Under low glucose conditions, CP-316819 facilitates glycogen utilization in the brain, prevents neuronal cell death and maintains brain electrical currents.

법적 정보

Sold for research purposes under agreement from Pfizer Inc.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable