추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
lyophilized powder
종 반응성
rat
기술
immunohistochemistry: suitable using rat embryo DRG
western blot: 1:200 using rat dorsal root ganglion (DRG) lysates
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
rat ... P2rx3(81739)
일반 설명
The P2X3 (purinergic receptor P2X 3) receptor is expressed in primary afferent neurons. It is a subtype of P2X receptors family of ligand-gated ion channels, activated by extracellular ATP (adenosine triphosphate).
면역원
peptide (C)VEKQSTDSGAYSIGH corresponding to residues 383-397 of rat P2rx3.
애플리케이션
Anti-Purinergic Receptor P2X3 antibody has been used in immunohistochemistry.
생화학적/생리학적 작용
The P2X3 (purinergic receptor P2X 3) plays a major role in the transmission of pain. Inducing P2X3 generates a desensitizing transient response and initiating P2X2/3 creates a relatively persistent response. P2X3 decreases the sympathetic tone in SH rats.
표적 설명
The P2X3 receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X3/P2X2). ATP released from damaged cells activates the P2X3 receptor to initiate nociceptive signals. Involvement of ATP in the mechanism of chronic pain contributes to P2X3 receptor as a possible target for the development of pain therapeutics.
물리적 형태
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.
재구성
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Purinergic receptors in the carotid body as a new drug target for controlling hypertension.
Pijacka W, et al.
Nature Medicine, 22(10), 1151-1151 (2016)
P2X3 receptor involvement in endometriosis pain via ERK signaling pathway.
Ding S, et al.
PLoS ONE, 12(9), e0184647-e0184647 (2017)
LncRNA uc. 48+ is involved in diabetic neuropathic pain mediated by the P2X 3 receptor in the dorsal root ganglia.
Wang S, et al.
Purinergic Signaling, 12(1), 139-148 (2016)
Bradykinin contributes to sympathetic and pressor responses evoked by activation of skeletal muscle afferents P2X in heart failure.
Xing J and Li J
Cellular Physiology and Biochemistry, 39(6), 2101-2109 (2016)
F Florenzano et al.
Neuroscience, 115(2), 425-434 (2002-11-08)
ATP released in the extracellular space by neuronal injury can influence neighboring neurons via activation of purinergic receptors. In vitro data suggest the involvement of ATP and purinergic receptors as trophic agents in different biological events such as neuritogenesis and
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