추천 제품
Quality Level
분석
≥98% (HPLC)
양식
solid
색상
white
solubility
DMSO: ~9 mg/mL
주관자
Novartis
SMILES string
O=C1CC2=C(C=CC=C2)N(C(N)=O)C3=CC=CC=C31
InChI
1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)
InChI key
CTRLABGOLIVAIY-UHFFFAOYSA-N
유전자 정보
human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
rat ... Scnn1g(24768)
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관련 카테고리
일반 설명
Oxcarbazepine (OXC) is the keto-analog of carbamazepine. Unlike carbamazepine, oxcarbazepine has no side effects. It is an antiepileptic drug, with an antineuralgic property. It has a pharmacokinetic advantage over carbamazepine. It is prescribed for neuropathic pain and serves as an effective pain reliever in trigeminal neuralgia. The catabolism of OXC to its monohydroxy derivative has significant pharmacologic property. It modulates potassium channels and voltage-dependent sodium channels. OXC modulates V2 receptor-G protein complex in collecting tubules and is used for treating diabetes insipidus.
애플리케이션
Oxcarbazepine has been used in reversed-phase high-performance liquid chromatography of human epileptic brain endothelial cells.
생화학적/생리학적 작용
Anticonvulsant, antineuralgic. Inhibits veratrine-induced transmitter release.
특징 및 장점
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
Joanna M Zakrzewska et al.
Pain, 95(3), 259-266 (2002-02-13)
Trigeminal neuralgia is a recurrent severe shooting neuropathic pain which can be managed both pharmacologically and surgically. However, there are no prospective data that compare these two therapeutic strategies. This study therefore aimed to assess long-term outcome in patients with
E Perucca
Fundamental & clinical pharmacology, 15(6), 405-417 (2002-02-28)
Although older generation antiepileptic drugs (AEDs) such as carbamazepine, phenytoin and valproic acid continue to be widely used in the treatment of epilepsy, these drugs have important shortcomings such as a highly variable and nonlinear pharmacokinetics, a narrow therapeutic index
Oxcarbazepine: Drug of the Future in the Treatment of Trigeminal Neuralgia.
Chole R, et al.
Journal of Indian Academy of Oral Medicine and Radiology, 23(1), S340-S343 (2011)
Oxcarbazepine Therapy for Complete Central Diabetes Insipidus.
Abdallah B, et al.
Case Reports in Neurological Medicine, 8(1), 20-24 (2018)
Clinical pharmacogenetics implementation consortium guideline for HLA genotype and use of carbamazepine and oxcarbazepine: 2017 update.
Phillips EJ, et al.
Clinical Pharmacology and Therapeutics, 103(4), 574-581 (2018)
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