N149

Nimodipine

• 동의어(들): 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• 실험식(Hill 표기법): C₂₁H₂₆N₂O₇
• CAS Number: 66085-59-4
• Molecular Weight: 418.44
• EC Number: 266-127-0
• MDL number: MFCD00153848
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277858
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 200
• 양식: powder
• 색상: off-white to yellow
• solubility: methanol: 62.5 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: insoluble; H₂O: insoluble
• 주관자: Bayer
• SMILES string: COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
• InChI: 1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
• InChI key: UIAGMCDKSXEBJQ-UHFFFAOYSA-N
• 유전자 정보: human ... ADORA3(140) , CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , CACNG1(786) , NR3C2(4306) ; rat ... Adora1(29290) , Adora2a(25369)

설명

애플리케이션

Nimodipine has been used:

• as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections
• as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC)
• in the pharmacological studies for the measurement of spine voltage escape

생화학적/생리학적 작용

Nimodipine enhances the survival of dopaminergic substantia nigra neurons.

Nimodipine is a potent L-type Ca²⁺ channel antagonist.

특징 및 장점

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

주의사항

Photosensitive

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves