추천 제품
제품명
Monoclonal Anti-Myelin Basic Protein (MBP) (36-50) antibody produced in rat, clone 14, tissue culture supernatant
생물학적 소스
rat
Quality Level
결합
unconjugated
항체 형태
tissue culture supernatant
항체 생산 유형
primary antibodies
클론
14, monoclonal
포함
0.09% sodium azide
종 반응성
horse, chicken, human
기술
ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
동형
IgG
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... MBP(4155)
일반 설명
Myelin basic protein (MBP) is part of the myelin sheath and is a calcium-dependent protein. It has six isoforms and the gene encoding it is localized on human chromosome 18q23.
특이성
Recognizes amino acids 36-50 of myelin basic protein.
면역원
bovine myelin basic protein.
생화학적/생리학적 작용
Myelin basic protein (MBP) associates with calmodulin and has been identified as an auto-antigen in multiple sclerosis (MS). It also inhibits the assembly of amyloid-β protein.
제조 메모
Generated by somatic cell hybridization of NS0 myeloma cells with spleen cells from an outbred rat immunized with bovine myelin basic protein.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Alexey Belogurov et al.
The Journal of biological chemistry, 289(25), 17758-17766 (2014-04-18)
The vast majority of cellular proteins are degraded by the 26S proteasome after their ubiquitination. Here, we report that the major component of the myelin multilayered membrane sheath, myelin basic protein (MBP), is hydrolyzed by the 26S proteasome in a
Neha Soni et al.
Frontiers in neurology, 11, 153-153 (2020-03-27)
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Chikashi Terao et al.
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Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and a typical complex trait. Although several genetic determinants have been identified, they account for only a part of the genetic susceptibility. We conducted a genome-wide association study
Angela L Cumberland et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 58, 50-58 (2017-02-14)
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