콘텐츠로 건너뛰기
Merck
모든 사진(1)

주요 문서

M8693

Sigma-Aldrich

Melanotan II acetate salt

≥95% (HPLC)

동의어(들):

Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2

로그인조직 및 계약 가격 보기
모든 사진(1)

About This Item

실험식(Hill 표기법):
C50H69N15O9 · xC2H4O2
CAS Number:
121062-08-6
Molecular Weight:
1024.18 (free base basis)
MDL number:
MFCD06795842
UNSPSC 코드:
51111800
NACRES:
NA.32

Quality Level

200

분석

≥95% (HPLC)

양식

lyophilized solid

색상

white

solubility

H2O: soluble 5 mg/mL

배송 상태

dry ice

저장 온도

−20°C

SMILES string

[nH]1cncc1C[C@@H]2NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC2=O)Cc5ccccc5)CCCN=C(N)N)Cc3c4c([nH]c3)cccc4)C(=O)N)NC(=O)[C@@H](NC(=O)C)CCCC

InChI

1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1

InChI key

JDKLPDJLXHXHNV-MFVUMRCOSA-N

유전자 정보

human ... MC3R(4159) , MC4R(4160)
mouse ... MC3R(17201) , MC4R(17202)
rat ... MC3R(29310) , MC4R(25635)

관련 카테고리

Amino Acid Sequence

Ac-Nle-Asp-His-Phe-Arg-Trp-Lys-NH2

일반 설명

Melanotan II induces melanogenesis and thus increases skin pigmentation. It is an analog of α-melanocyte stimulating hormone.

애플리케이션

Melanotan II acetate salt has been used to study its inhibitory effects on feeding and energy expenditure in rats.

생화학적/생리학적 작용

Melanotan II is a MC3-R/MC4-R melanocortin agonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
026M4750V
025M4770V
072M4733V
091M4715V
100M4735V

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Kristian Thestrup-Pedersen et al.
Ugeskrift for laeger, 173(13), 975-975 (2011-04-02)
A 25-year-old man had self-injected more than 150 doses of melanotan to increase his skin pigmentation, which had increased significantly. At the same time, his nevi had become darker and new nevi and lentigines developed; they also occurred on his
[Eruptive dysplastic nevi following melanotan use].
L Hueso-Gabriel et al.
Actas dermo-sifiliograficas, 103(4), 329-331 (2012-03-20)
Zeng-You Ye et al.
Regulatory peptides, 166(1-3), 112-120 (2010-10-13)
Sympathetic nerve activity is increased in obesity-related hypertension. However, the central mechanisms involved in the increased sympathetic outflow remain unclear. The hypothalamic melanocortin system is important for regulating energy balance and sympathetic outflow. To understand the mechanisms by which the
Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets
Jose K
Frontiers in Behavioral Neuroscience (2015)
John-Paul Baird et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 301(4), R1044-R1056 (2011-07-08)
Injections of the melanocortin 3/4 receptor (MCR) agonist melanotan II (MTII) to a variety of brain structures produces anorexia, suggesting distributed brain MCR control of food intake. We performed a detailed analysis of feeding behavior (licking microstructure analysis) after a
모든 관련된 서류 보기

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.