M5750

Menadione sodium bisulfite

≥95% (TLC)

• 동의어(들): 2-Methyl-1,4-naphthoquinone sodium bisulfite
• 실험식(Hill 표기법): C₁₁H₉NaO₅S
• CAS Number: 130-37-0
• Molecular Weight: 276.24
• EC Number: 204-987-0
• MDL number: MFCD00051456
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24897038
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥95% (TLC)
• 양식: powder
• 색상: white to off-white
• solubility: H₂O: ≥50 mg/mL, clear, colorless to faintly yellow
• 응용 분야: cell analysis
• 주관자: Eli Lilly
• 저장 온도: −20°C
• SMILES string: [Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O
• InChI: 1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1
• InChI key: XDPFHGWVCTXHDX-UHFFFAOYSA-M

설명

애플리케이션

Menadione sodium bisulfite has been used:

• as a priming agent in tomato for improving salt tolerance
• to induce reactive oxygen species (ROS) in human lung epithelium BEAS-2B microtissues
• to induce endogenous superoxide production in mouse C17.2 neural stem cells

생화학적/생리학적 작용

Menadione sodium bisulfite is a water-soluble form of menadione, which belongs to the Vitamin K class of compounds. These are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione is a prothrombogenic compound and is used as a model quinone in cell culture and in vivo investigations.

Menadione has been shown to affect gap-junctional intercellular communication by mediation of tyrosine phosphorylation. Menadione has demonstrated cytotoxic activity against a variety of cell lines and can induce apoptosis in cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels.

An HPLC method for detection of menadione sodium bisulfite in multivitamin formulations has been published. A chemiluminescence assay for menadione sodium bisulfite in pharmaceutical preparations and biological fluids has been reported.

특징 및 장점

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

기타 정보

Water soluble vitamin K₃.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H410
• 예방조치 성명서: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves