추천 제품
Quality Level
분석
>98% (HPLC)
양식
oil
색상
colorless to light brown
solubility
DMSO: >10 mg/mL
H2O: insoluble
배송 상태
wet ice
저장 온도
2-8°C
SMILES string
CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(CC)nc1-c2ccccc2
InChI
1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3
InChI key
UUSHFEVEROROSP-UHFFFAOYSA-N
유전자 정보
human ... ADORA3(140)
rat ... Adora1(29290) , Adora2a(25369) , Adora3(25370)
애플리케이션
MRS 1523 has been used as an inhibitor of adenosine receptors in SW1990 and BxPC3 pancreatic cancer cells, LX2 human hepatic stellate cells and human coronary smooth muscle cells.
생화학적/생리학적 작용
MRS 1523 is a selective adenosine A3 receptor antagonist in the rat.
특징 및 장점
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
법적 정보
Sold under license from the National Institutes of Health
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves
이미 열람한 고객
C H Mitchell et al.
The American journal of physiology, 276(3 Pt 1), C659-C666 (1999-03-10)
Adenosine stimulates Cl- channels of the nonpigmented (NPE) cells of the ciliary epithelium. We sought to identify the specific adenosine receptors mediating this action. Cl- channel activity in immortalized human (HCE) NPE cells was determined by monitoring cell volume in
A H Li et al.
Journal of medicinal chemistry, 41(17), 3186-3201 (1998-08-14)
The structure-activity relationships of 6-phenyl-1,4-dihydropyridine derivatives as selective antagonists at human A3 adenosine receptors have been explored (Jiang et al. J. Med. Chem. 1997, 39, 4667-4675). In the present study, related pyridine derivatives have been synthesized and tested for affinity
The A3 adenosine receptor agonist, namodenoson, ameliorates non-alcoholic steatohepatitis in mice
Fishman P, et al.
International Journal of Molecular Medicine, 44(6), 2256-2264 (2019)
Shira Cohen et al.
Journal of immunology research, 2018, 2310970-2310970 (2018-06-05)
Interleukin-17 and interleukin-23 play major roles in the inflammatory process in psoriasis. The Gi protein-associated A3 adenosine receptor (A3AR) is known to be overexpressed in inflammatory cells and in peripheral blood mononuclear cells (PBMCs) of patients with autoimmune inflammatory conditions.
Nathaniel A Sowa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(31), 10282-10293 (2010-08-06)
Prostatic acid phosphatase (PAP) is expressed in nociceptive dorsal root ganglion (DRG) neurons, functions as an ectonucleotidase, and generates adenosine extracellularly. Here, we found that PAP inhibits noxious thermal sensitivity and sensitization that is associated with chronic pain through sustained
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