추천 제품
양식
ethanol solution
Quality Level
배송 상태
dry ice
저장 온도
−20°C
SMILES string
CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
InChI
1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
InChI key
IXAQOQZEOGMIQS-SSQFXEBMSA-N
생화학적/생리학적 작용
Lipoxin A4 (LXA4) is synthesized from arachidonic acid and is an endogenous lipoxygenase-derived eicosanoid mediator. It is a potent human protein kinase C activator. It inhibits cytotoxicity of natural killer cells. LXA4 regulates the immune system and inflammation. In the brain, it modulates neuronal signaling and slow wave sleep. LXA4 binds to cannabinoid receptors. LXA4 plays a key role in the maintenance of endometrium and reproductive function. Depletion of LXA4 contributes to the pathophysiology of cystic fibrosis (CF).
포장
Packaged under argon.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point (°F)
55.4 °F
Flash Point (°C)
13 °C
개인 보호 장비
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Physiological impact of abnormal lipoxin A4 production on cystic fibrosis airway epithelium and therapeutic potential.
Higgins G, et al.
BioMed Research International, 2015(3), 439-439 (2015)
Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor.
Pamplona FA, et al.
Proceedings of the National Academy of Sciences of the USA, 109(51), 21134-21139 (2012)
Stephanie G Dakin et al.
Scientific reports, 7(1), 11009-11009 (2017-09-10)
The mechanisms underpinning the failure of inflammation to resolve in diseased musculoskeletal soft tissues are unknown. Herein, we studied bioactive lipid mediator (LM) profiles of tendon-derived stromal cells isolated from healthy donors and patients with chronic tendinopathy. Interleukin(IL)-1β treatment markedly
The role of lipoxin A 4 in endometrial biology and endometriosis.
Canny GO and Lessey BA
Mucosal Immunology, 6(3), 439-439 (2013)
The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo.
Chiang N, et al.
Pharmacological Reviews, 58(3), 463-487 (2006)
문서
The potential for the prevention and treatment of cardiovascular disease through increased dietary intake of omega-3 (w-3) fish oils is not a recent scientific discovery.
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